Parkinson's Disease-on-a-Chip Model Introduction

The Parkinson's disease-on-a-chip model of Creative Biolabs will advance your understanding of the aggregated forms in the development of the disease and the induction of neuronal toxicity.

Parkinson's Disease-on-a-chip Model

For the Parkinson's disease-on-a-chip model, we leveraged our previously organs-chip design, which consists of two microfluidic channels fabricated from polydimethylsiloxane (PDMS) elastomer separated by a thin PDMS membrane containing multiple pores. Each route has committed inlet and outlet ports for the seeding of the human cells, that are kept under reservation, solely for each channel, laminar flow applied.

Fig 1. Schematic depiction of the substantia nigra brain-chip. (Pediaditakis, 2021)

Advantages of Our Parkinson's Disease-on-a-chip Model

• Specialized imaging and frequent sampling.
• Maintain nutrient concentrations and sufficient fluid flow.
• Recapitulate the cell-cell interactions and cytoarchitecture at the neurovascular unit.
• Receptive to depicting and conservative stages used in both in vivo and in vitro research. The isogenic model forms from all originated cell types of the same human individual.
• An isogenic model with all cell types originating from the same human individual.

Applications of Parkinson's Disease-on-a-chip Model

• Disclosing the aspects of the particular intercourses between the brain parenchymal cells in both pathological and normal phenomenon.
• Show activation of astrocytes and microglia, in line with the active inflammatory process in the substantia nigra in patients with Parkinson's Disease (PD).
• Allow regular evaluating of the outflowing from each side of the membrane, which assess the barrier permeability.
• Enable the most precise characterization of cell-cell interactions and personalized medicine applications.

Why Choose Us

Our Parkinson's disease-on-chip model can be called into play as a platform for evaluating the efficacy of therapies against PD and other synucleinopathies, target validation, and target identification. In addition, our results will support you in further investigation of gene therapy for neurodegenerative diseases.

Besides the Parkinson's disease-on-a-chip model, we have a range of other models that may help you:

Related Services

At Creative Biolabs, we envision more than just offering research models and samples. With our extensive experience and profound expertise in 3D biology, we are pound to introduce all-encompassing one-stop services along with comprehensive technical support. Don't hesitate to contact us at any time to explore how we can drive your project towards swift success.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction