Oncology-on-a-Chip Model Introduction

At Creative Biolabs, we can provide you with cleverly designed oncology-on-a-chip models. The models can recapitulate human disease and feature both patient cancer cells and human immune cells, which are of utmost importance to increase the success rates in immunotherapy discovery and development.

Formation of Oncology-on-a-chip Model

Oncology-on-a-chip model includes a vertical tissue-tissue interface. One advantage of such an interface is the easy visualization of the dynamic cellular interaction and migration in the lateral dimension, as the resolution and optical accessibility in the x-/y-direction is generally higher than in the z-direction. Several techniques have been developed to create this interface, including sequential hydrogel photopatterning, micro-molding, as well as capillary pinning e.g., by using a series of regularly spaced pillars. These approaches have been used to analyze the migration dynamics of natural killer (NK) cells, genetically engineered T cells, dendritic cells, neutrophils, and monocytes into the tumor mass. Furthermore, such connections also enable lateral fluid dissemination and have been resort to assess the diffusion of immunomodulatory nanoparticles over the endothelial hurdle into the tumor mass.

Fig 1. Compartmentalization of 3D tissues in immunocompetent cancer-on-a-chip (iCoC) models. (Maulana, 2021)

Advanced Oncology-on-a-chip Model at Creative Biolabs

• Comprises three-dimensional (3D) cancer tissue integrated within a tumor microenvironment (TME) featuring vascularization and immune components.
• Dynamically adapts to stimuli from the tumor.
• Mimics the key functional units of immune cell interaction.

Applications of Oncology-on-a-chip Model

Why Choose Us

Creative Biolabs' oncology-on-a-chip models serve as advanced human-based in vitro models that have been developed to allow you to deepen targeted mechanistic research, gain early information about on-target off-tumor and off-target toxicities, and increase confidence in the mechanisms of action.

In addition to the oncology-on-a-chip model, there is a range of other models at Creative Biolabs to consider:

Related Services

Expanding upon our diverse collection of disease-on-a-chip models, Creative Biolabs is dedicated to delivering top-notch 3D biology-based services, as outlined below, to our worldwide customers. We welcome you to initiate contact us to explore how our pioneering disease-on-a-chip models can enrich your research pursuits.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction