Creative Biolabs' spinal cord injury-on-a-chip model is a valuable tool for investigating neuronal damage at a cellular level. A specified, reproducible mechanical force has been developed to allow understanding of the complex biomedical mechanisms of spinal cord injuries and the therapeutic strategies for this condition.
The stretch model of our labs' neuronal injury utilizes a flexible substrate on which adherent neurons are cultured. Injury to the cell population is then applied through a substrate. The chip model has two mini-well compartments separated by micro-channels.
Fig 1. Diagrammatic illustration of an in vitro uniaxial stretch model. (Parittotokkaporn, 2021)
Our in vitro spinal cord injury-on-a-chip model has been described in the study field, including transection, compression, and acceleration injuries among others. The closely mimicking pathophysiological and functional features of the spinal cord injury-on-a-chip model can serve as an adequate model to develop and evaluate the structural and functional benefits of therapeutic strategies for spinal cord injuries.
Besides the spinal cord injury-on-a-chip model, we provide several alternative models that may be of significance to your studies:
In addition to comprehensive range of models, we also offer a selection of intimate preclinical research services based on 3D biology. With rich experience, our experts possess a deep understanding of varied research needs.
We welcome your inquiries whether technology or the model itself and are always happy to provide any assistance to your research. Please contact us at your convenience to learn more about our highly customizable disease-on-a-chip models and related services.
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