Diabetes-on-a-Chip Model Introduction

At Creative Biolabs, we aim at providing a basic understanding of modeling in diabetes by giving you an overview of selected, important in silico models for metabolic processes. The diabetes-on-a-chip model we present is chosen as a representative example for the according model type.

Formation of Diabetes-on-a-Chip Model

Diabetes mellitus is a disease that perturbs the crosstalk of multiple tissues, models incorporating multiple pancreatic cell types and organs are needed to recapitulate certain aspects of the disease.

Different 3D culture models exist for monogenic diabetes mellitus, type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM).Fig.1. Different 3D culture models exist for monogenic diabetes mellitus, type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). (Selcen, 2023)

Advanced Diabetes-on-a-Chip Model at Creative Biolabs

  • Simulate both micro- and macrovascular complications and every other possible outcome that is unlikely to test completely in clinical trials.
  • Our models are much less expensive and extensive.
  • High rate of parameter changes in our models that can be readjusted.
  • Empirically-based recommendation from our expert team for the required number of replications to ensure accurate results.

Applications of Diabetes-on-a-Chip Model

The diabetes-on-a-chip model brings breakthrough progress in the field of diabetes, ranging from simulating glucose regulation and insulin responses to investigating potential drug interventions and personalized treatment strategies. The specific applications include but not limited to:

  • Open the route for new treatment options and enables complex regulated systems.
  • Long time intervals can be modeled (years instead of months).
  • Provide insight into the dynamics of the glucose-insulin metabolism.
  • Provide evidence on the safety and effectiveness of nonadjunctive CGM use to support the approval of a CGM sensor.
  • Allows extracting better conclusions and answering multiple questions concerning, for example, intervention methods, treatment costs, consequences of imprecise medical devices or incorrect measurements.

Why Choose Us

Patients with diabetes highly depend on effective treatment options and the reliability of diagnostics devices for their diabetes management. The diabetes-on-a-chip model from Creative Biolabs can help decision-makers to highlight every possibility or outcome and find the right treatment for individual patients. It can also estimate long-term effects, therefore, reducing your costs of medication.

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Related Services

As technology advances and evolves, these disease-on-a-chip models prove particularly valuable in preclinical drug screening and prognosticating patient responses to specific treatments. With our extensive research background and a network of renowned experts, we are excited to provide dependable disease-on-a-chip models and associated technological services in your scientific journey. Reach out to us without hesitation for top-tier technical support.

Reference

  1. Selcen, B.; et al. Towards a better understanding of diabetes mellitus using organoid models. Nature Reviews Endocrinology. 2023, 19(4): 232-248.
Research Model

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