Normal Whole Cerebral Organoid Model

Glioma is a common brain tumor characterized by its poor prognosis and strong aggressiveness. The rapid growth and frequent recurrence after surgical removal reflect its refractory nature. Thus, there is an urgent need to settle the chemotherapy resistance problem. Developing a novel tool to study the cell dynamics of gliomas is considered a feasible method of exploring the disease features and more effective treatment strategies. In the disease field, Creative Biolabs has rich research experience and will be your trustworthy partner for the research on glioma mechanisms and the development of preclinical therapeutic strategies.

Construction of Normal Whole Cerebral Organoid Models

Normal cerebral organoids are a common type of normal neural organoids. With respect to their derivation, Xu et al. have verified a robust protocol. The normal cerebral organoids initiate from induced pluripotent stem cells (iPSC) and are next cultured into embryoid bodies. Through induction by a variety of growth factors, they gradually differentiate and finally generate cerebral tissues. The general culture process can be found in Fig.1.

Fig.1 Schematic of the method for generating engineered cerebral organoids. (Xu, 2021)

Advantages of Normal Whole Cerebral Organoid Models

Current research has found that it could make up for the shortcomings of traditional glioma models and displays the following advantages.

• Generalize the early stages of human brain development and help understand the brain structure in vitro.
• Possess the strong representational ability and good repeatability, which offers an evaluable platform for modeling brain diseases.
• Capture key characteristics of the human brain, such as cell distribution and organization, physiological structure, electrical activity and neuronal network.
• Faithfully reproduce the interaction between in vivo structure and microenvironment and are of more clinical significance than animal models.
• Create more possibilities for studying cancer progression when integrated with gene editing technology.

Applications of Normal Whole Cerebral Organoid Models

To our knowledge, normal cerebral organoids have been widely accepted as a good platform for glioma research since their emergence. They are very suitable for exploring glioma as well as its microenvironment, and can be employed to conduct disease modeling, toxicology testing, drug sensitivity test, personalized treatment and construct orthotropic xenografts. In view of the rapid development of microfluidic and organ-on-chip technology, such models display great potential for brain diseases in the near future.

Related Services

Creative Biolabs is leading in the 3D biology area and has been devoted to establishing 3D organoid models. Until now, we have accumulated a large and stable customer base, which proves our strength in ex vivo organoid modeling. In addition, we also provide 3D biology-based assay services to help our organoid products better apply to your projects. Please feel free to contact us at your convenience to discuss your project.

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