3D Ex Vivo Human Vasoconstriction Model in Coronary Arteries Introduction

Creative Biolabs has developed 3D ex vivo human vasoconstriction model in coronary arteries for global researchers in the field of cardiovascular disease.

Coronary Arteries Vasoconstriction

Coronary arteries are the blood vessels that supply the heart with oxygen and nutrients. The intricate network of coronary arteries is responsible for the proper functioning of the heart, and any obstruction or damage can lead to heart disease. Vasoconstriction in coronary arteries is a pathological condition that results in the narrowing of the blood vessels, leading to reduced blood flow to the heart is a leading cause of hospitalization and mortality. This condition can be caused by various factors, including hypertension, atherosclerosis, and other cardiovascular diseases.

Fig 1. Fluorescein staining of coronary arteries. (Maguire, 2014)

Why Choose 3D Ex Vivo Human Vasoconstriction Model in Coronary Arteries

Human coronary artery with side branches. (Vardhan, 2019)

Traditional Vasoconstriction Model in Coronary Arteries

Traditional models for studying coronary artery vasoconstriction include animal and cell culture models. However, these models have significant limitations, such as differences in anatomy and physiology between animals and humans and limited representativeness of the complex human coronary artery network. These problems often prevent researchers from successfully translating results into clinical trials after going through time-consuming and costly pre-validation.

3D Ex Vivo Human Vasoconstriction Model in Coronary Arteries

Creative Biolabs 3D ex vivo human vasoconstriction model in coronary arteries has been fully validated and characterized to provide unrivaled advantages for your vasoconstriction studies:

Accurate representation of the human coronary artery network;
Realistic simulation of vasoconstriction in human coronary arteries;
High degree of reproducibility and consistency;
Ethically sourced and available in large quantities;
Improved drug development process by testing drugs in a human-based model.

3D Ex Vivo Human Vasoconstriction Model in Coronary Arteries

What We Provide

Creative Biolabs is committed to providing worldwide researchers with high quality human biological specimens and human tissue-based ex vivo models. We ensure each specimen is collected in accordance with optimized protocols that conform to ethical guidelines. Particularly, we maintain extensive repositories to fulfill urgent demands and furnish personalized human tissue samples that cater to the specific experimental designs of our clients. In addition, we have also developed 3D ex vivo human vasoconstriction model in other tissues, such as saphenous vein, subcutaneous resistance arteries, and denuded coronary arteries. With our profound knowledge and steadfast dedication, we are fully confident in our ability to assist your projects. Please feel free to contact us for more detailed information.

References

Maguire, J.J.; et al. The CCR5 chemokine receptor mediates vasoconstriction and stimulates intimal hyperplasia in human vessels in vitro. Cardiovascular Research. 2014, 101: 1-9.
Vardhan, M.; et al. The importance of side branches in modeling 3D hemodynamics from angiograms for patients with coronary artery disease. Nature. 2019, 9: 8854.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

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Research Model

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