3D Ex Vivo Human Vasoconstriction Model in Saphenous Vein Introduction

Creative Biolabs has successfully developed 3D ex vivo human vasoconstriction model in saphenous vein, a valuable tool for understanding the mechanisms of vasoconstriction and its impact on cardiovascular disease.

Saphenous Vein vasoconstriction

Saphenous vein. (Joddar, 2015)

The saphenous vein is a large, superficial vein in the leg that is commonly used for coronary artery bypass graft surgery. It plays an important role in blood circulation by carrying deoxygenated blood from the lower leg back to the heart.

Vasoconstriction is a process in which the smooth muscle surrounding blood vessels contracts, leading to a reduction in vessel diameter and blood flow. This process can contribute to hypertension, atherosclerosis, and other cardiovascular diseases. Researchers have long sought to understand the molecular and cellular mechanisms behind vasoconstriction, with the goal of developing new therapies to treat these conditions.

Why Choose 3D Ex Vivo Human Vasoconstriction Model in Saphenous Vein?

Transversal sections of saphenous vein. (Garoffolo, 2020)

Traditional Models and Limitations

Traditionally, researchers have relied on animal models or cell cultures to study vasoconstriction. While these models have been useful, they also have limitations. Animal models can be expensive and may not accurately reflect human physiology with ethical concerns, while cell cultures may not fully capture the complexity of interactions between different cell types in vivo.

3D Ex Vivo Human Vasoconstriction Model in Saphenous Vein

The 3D ex vivo human human vasoconstriction model in saphenous vein offers several advantages over traditional models. The use of human tissue closely resembles the physiology of humans more than animal models or cell cultures. The 3D nature of the model allows for the study of interactions between different cell types in a more natural environment. Such model can be used to study the effects of drugs and other therapies on vasoconstriction in a more physiologically relevant setting.

3D Ex Vivo Human Vasoconstriction Model in Saphenous Vein

What We Provide?

Creative Biolabs provides high-quality 3D ex vivo human vasoconstriction models in saphenous vein for molecular biology and other research applications. We persist in a rigorous review process to ensure ethical availability and quality. In addition, we also provide 3D ex vivo human sasoconstriction models derived from multiple arteries, such as subcutaneous resistance arteries, coronary arteries, and denuded coronary arteries. Please feel free to contact us for more information.

References

Joddar, B.; et al. Arterial levels of oxygen stimulate intimal hyperplasia in human saphenous veins via a ROS-dependent mechanism. PLOS ONE. 2015, 10(3): e0120301.
Garoffolo, G.; et al. Coronary artery mechanics induces human saphenous vein remodeling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1. Theranostics. 2020, 10(6): 2597.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

3D Ex Vivo Human Vasoconstriction Model in Saphenous Vein Introduction

Saphenous Vein vasoconstriction

Why Choose 3D Ex Vivo Human Vasoconstriction Model in Saphenous Vein?

What We Provide?

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