3D Ex Vivo Human Vasoconstriction Model in Subcutaneous Resistance Arteries Introduction

Creative Biolabs provides 3D ex vivo human vasoconstriction model in subcutaneous resistance arteries for our clients all over the world.

Subcutaneous Resistance Arteries Vasoconstriction

Subcutaneous resistance arteries, which are found in the skin, play a significant role in peripheral arterial blood pressure regulation by regulating blood flow. The narrowing of blood vessels, known as vasoconstriction, reduces blood flow and increases vascular resistance. As usual, vasoconstriction is a crucial factor in various cardiovascular diseases, including heart failure, atherosclerosis, and hypertension. Therefore, comprehending the mechanisms that cause vasoconstriction is vital in developing effective treatments for these medical conditions.

Fig 1. Human subcutaneous resistance arteries tissue. (Lang, 2007)

Why Choose 3D Ex Vivo Human Vasoconstriction Model in Subcutaneous Resistance Arteries

Collagen, elastin and cell nuclei stain images of artery vessel. (Bell, 2016)

Traditional Models for Vasoconstriction

Current methods for studying vasoconstriction in subcutaneous resistance arteries have significant limitations. Animal models can be expensive, time-consuming, and ethically challenging. Additionally, they do not always replicate human physiology accurately. Isolated primary cells are also challenging to obtain, and their response to stimuli may differ from in vivo conditions. Moreover, 2D cell culture does not reflect the complex architecture of blood vessels in vivo.

3D Ex Vivo Human Vasoconstriction Model in Subcutaneous Resistance Arteries

Creative Biolabs' 3D ex vivo human vasoconstriction model in subcutaneous resistance arteries provides a more accurate representation of human physiology. Compared with traditional methods, the model preserves the complex microenvironment of blood vessels, allowing for more realistic simulations of in vivo conditions. Particularly, the 3D structure of the model provides a more realistic representation of the architecture of blood vessels than isolated cells, making it an excellent tool for studying complex cellular interactions.

Vasoconstriction model in subcutaneous resistance arteries. (Creative Biolabs)

What We Provide?

Creative Biolabs is committed to delivering high quality human biological specimens and human tissue-based ex vivo models for global scientists. Our team performs meticulous pathological examination and data collection for each sample, to meeting the specific requirements of various research projects. In addition to 3D ex vivo human vasoconstriction model in subcutaneous resistance arteries, we also provide other 3D ex vivo human vasoconstriction model in other types of positions, such as saphenous vein, coronary arteries, and denuded coronary arteries. For more detailed information, please feel free to contact us.

References

Lang, N.N.; et al. Connexin 43 mediates endothelium-derived hyperpolarizing factor-induced vasodilatation in subcutaneous resistance arteries from healthy pregnant women. American Journal of Heart and Circulatory Physiology. 2007, 292: 1026-1032.
Bell, J.S.; et al. Microstructure and mechanics of human resistance arteries. American Journal of Heart and Circulatory Physiology. 2016, 311(6): 1560-1568.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

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