3D Ex Vivo Human Vasoconstriction Model in Denuded Coronary Arteries Introduction

Creative Biolabs focuses on the innovation of 3D ex vivo human vasoconstriction modeling technology, and is committed to providing customers with a complete solution and personalized service for 3D ex vivo human vasoconstriction models in denuded coronary arteries.

Vasoconstriction Model in Denuded Coronary Arteries

The coronary arteries are contractile and are responsible for supplying blood to the myocardium to ensure normal metabolic activity. Sudden constriction of coronary arteries causes arterial blockage and obstruction of blood flow, and the contractile response produced by the denuded coronary artery is exacerbated by the release of relaxing factors secreted by exempt endothelial cells. Thus, 3D ex vivo reconstruction of the vasoconstriction model in denuded coronary arteries may offer the possibility to simulate the physiological behavior of vasoconstriction and cardiovascular pathology.

Coronary arteries constriction causes pathological spasms.Fig 1. Coronary arteries constriction causes pathological spasms. (Rehan, 2022)

Conventional Vasoconstriction Model

  • Existing means of constructing vasoconstriction models are generally limited to a specific scale and have very limited reproduction of the vascular network, mostly relying on the chemical induction of expensive vasoconstrictors.
  • The lack of a universal method for the flexible construction of individualized structural and functional in vitro models has so far severely limited the progress of disease research as well as drug development.

VS

3D Ex Vivo Human Vasoconstriction

  • 3D ex vivo human vasoconstriction model in denuded coronary arteries offers new ideas for studying the interaction between disease and blood vessels.
  • The model allows the simulation of vasoconstriction in the cardiovascular disease induction process, drug screening, and the study of vascular barrier function to drugs and provides a feasible tool.

Why Choose Creative Biolabs?

3D Ex Vivo Human Vasoconstriction Model in Denuded Coronary Arteries

3D Ex Vivo Human Vasoconstriction Model in Denuded Coronary Arteries

Multistage network of denuded coronary arteries and associated vessels containing several millimeters to several micrometers in size.

The multilevel network has mechanisms involved in vasoconstrictor activity for the diversification of vascular physiological and pathological scenarios.

Our 3D modeling platform builds complex and accurate 3D models based on real in vivo vasoconstriction and related pathological data in order to model stability, aiding the completion of cardiovascular disease mechanism studies and drug intervention simulations.

Our Services

As a leading global provider of 3D biological models and value-added services, Creative Biolabs understands your need for vasoconstriction models. We rely on a vast platform of 3D modeling facilities to develop proprietary solutions to simulate real tissue viability. A wide range of high-quality vasoconstriction model products are ideally suited to support scientific research and drug discovery in cardiovascular disease and related complications.

Creative Biolabs has accumulated expert insight into the physiology of denuded coronary arteries and vasoconstriction systems, supported with high-quality supply systems, as the ideal service team to provide 3D ex vivo human vasoconstriction model in denuded coronary arteries. Please feel free to contact us for a reliable and customized solution.

Reference

  1. Rehan, R.; et al. Coronary vasospastic angina: a review of the pathogenesis, diagnosis, and management. Life (Basel). 2022, 12(8): 1124.
Research Model

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